Mixed phenotype acute leukemia ( MPAL ) : clinical and laboratory features and outcome in 100 patients defined according to the WHO 2008 classification
نویسندگان
چکیده
Affiliations: (1) Departments of Haemato-Oncology and (2) Statistics. Royal Marsden Hospital. Institute of Cancer Research. London, England (3) Institute of Immunology. Center for Pathophysiology Infectiology and Immunology. Medical University of Vienna. Austria (4) Department of Haematology, Erasmus MC. Rotterdam. The Netherlands (5) St Anna Children’s Hospital. Vienna. Austria (6) Medical Department III, Hanusch Hospital. Vienna. Austria (7) Immunology, CHU&Faculty of Medicine, Nancy University, France Blood First Edition Paper, prepublished online January 12, 2011; DOI 10.1182/blood-2010-10-314682
منابع مشابه
Mixed phenotype acute leukemia (MPAL): clinical and laboratory features and outcome in 100 patients defined according to the WHO 2008 classification Authors:
Affiliations: (1) Departments of Haemato-Oncology and (2) Statistics. Royal Marsden Hospital. Institute of Cancer Research. London, England (3) Institute of Immunology. Center for Pathophysiology Infectiology and Immunology. Medical University of Vienna. Austria (4) Department of Haematology, Erasmus MC. Rotterdam. The Netherlands (5) St Anna Children’s Hospital. Vienna. Austria (6) Medical Dep...
متن کاملMixed-phenotype acute leukemia: clinical and laboratory features and outcome in 100 patients defined according to the WHO 2008 classification.
The features of 100 mixed-phenotype acute leukemias (MPALs), fulfilling WHO 2008 criteria, are documented. Myeloid and T-lineage features were demonstrated by cytoplasmic myeloperoxidase and CD3; B-lineage features were demonstrated by at least 2 B-lymphoid markers. There were 62 men and 38 women; 68% were adults. Morphology was consistent with acute lymphoblastic leukemia (ALL; 43%), acute mye...
متن کاملMixed-phenotype acute leukemia: suboptimal treatment when the 2008/2016 WHO classification is used
BACKGROUND Different criteria have been used to diagnose mixed-phenotype acute leukemia (MPAL), which has impacted the number of individuals diagnosed with this pathology. Better outcomes have been reported when using acute lymphoblastic leukemia (ALL)-type chemotherapy in the treatment of MPAL. METHODS We compared the outcome of 4 groups of patients with MPAL. Group 1 included patients diagn...
متن کاملMixed-phenotype acute leukemia: disease features and outcome.
EM MPAL is a very rare form of acute leukemia; the precise incidence among acute leukemias is difficult to establish. According to approximate figures from the centers involved in our European Group for the Immunological Classification of Leukemias (EGIL), approximately 0.5–1% of acute leukemia cases are MPAL, including pediatric and adult cases. It is very likely that MPAL derives from the neo...
متن کاملPresenting Clinical and Laboratory Data of Childhood Acute Lymphoblastic Leukemia
Abstract Background Leukemia is the most prevalent childhood cancer and Acute Lymphoblastic Leukemia (ALL) constitutes 75% of all cases. The most frequent presenting symptoms are fever, weight loss and pallor. Early detection of clinical symptoms positively affects timely diagnosis. The objectives of the present study were to assess frequency of presenting symptoms, laboratory data, immune ph...
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تاریخ انتشار 2011